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Objective:To analyze the incidence and epidemiological characteristics of traumatic spinal cord injury in China in 2018.Methods:Multi-stage stratified cluster sampling was used to randomly select hospitals capable of treating patients with spinal cord injury from 3 regions，9 provinces and 27 cities in China to retrospectively investigate eligible patients with traumatic spinal cord injury admitted in 2018. National and regional incidence rates were calculated. The data of cause of injury，injury level，severity of injury，segment and type of fracture，complications，death and other data were collected by medical record questionnaire，and analyzed according to geographical region，age and gender.Results:Medical records of 4，134 patients were included in this study，with a male-to-female ratio of 2.99∶1. The incidence of traumatic spinal cord injury in China in 2018 was 50.484 / 1 million （95% CI 50.122-50.846）. The highest incidence in the Eastern region was 53.791 / 1 million （95% CI 53.217-54.365）. In the whole country，the main causes of injury were high falls （29.58%），as well as in the Western region （40.68%），while the main causes of injury in the Eastern and Central regions were traffic injuries （31.22%，30.10%）. The main injury level was cervical spinal cord in the whole country （64.49%），and the proportion of cervical spinal cord injury in the Central region was the highest （74.68%），and the proportion of lumbosacral spinal cord injury in the Western region was the highest （32.30%）. The highest proportion of degree of injury was incomplete quadriplegia （55.20%），and the distribution pattern was the same in each region. A total of 65.87% of the patients were complicated with fracture or dislocation，77.95% in the Western region and only 54.77% in the Central region. In the whole country，the head was the main combined injury （37.87%），as well as in the Eastern and Central regions，while the proportion of chest combined injury in the Western region was the highest （38.57%）. A total of 32.90% of the patients were complicated with respiratory complications. There were 23 patients （0.56%） died in hospital，of which 17（73.91%） died of respiratory dysfunction. Conclusions:The Eastern region of China has a high incidence of traumatic spinal cord injury. Other epidemiological features include high fall as the main cause of injury cervical spinal cord injury as the main injury level，incomplete quadriplegia as the main degree of injury，head as the main combined injury，and respiratory complications as the main complication.
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With the acceleration of the population aging in China, the health problems and the demands of health services such as health check-up for rural residents should attract the attention of the whole society. The group standard entitled Health check-up guide for rural residents (T/CHAA 005-2019), was written by experienced researchers from Chinese Center for Disease Control and Prevention and other professional institutes coordinated by Chinese Health Association. The standard aims to establish a service model that takes health information collection as a means, health risk assessment, health risk intervention and information services as the core, improving the health of rural residents as the target.
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OBJECTIVE: To identify the poor working posture on musculoskeletal disorders of workers in greenhouse vegetable plantation(hereinafter referred to as “vegetable workers”) in different planting stages, and to evaluate the risk grade of working posture. METHODS: A total of 28 vegetable workers in a greenhouse vegetable planting base in Shandong Province were taken as research subjects using convenient sampling method. Video data were collected from field observation. Working posture analysis system was used to code the working posture of vegetable workers. The composition of working posture was analyzed, and the risk grade of working posture was evaluated. RESULTS: In the planting and seedling period, the main poor working postures of workers were lumbar back leaning forward, legs squatting, lumbar back bending, and legs bending, and the composition ratios were 60.4%, 42.9%, 38.6% and 38.4% respectively. In the management period, the main poor working postures were neck forward, waist back bending, hands higher than elbows, and the composition ratios were 52.0%, 34.2% and 30.0% respectively. In the harvest period, the main poor working postures were neck leaning forward, one hand above elbow, lumbar back bending, walking and lumbar back leaning, and the composition ratios were 50.4%, 42.6%, 39.6%, 39.1% and 35.4% respectively. In the period of planting and seedling, management and harvest, there were 81.6%, 23.4% and 52.9% of the work position in the risk grade Ⅲ; there was 1.4% of the work position in the risk grade Ⅳ in the harvest period. CONCLUSION: Working postures with obvious hazards existed at different planting periods. Effective intervention measures should be taken to prevent the problems of poor working posture in greenhouse workers.
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Analyses of the multivariate regression model are ued very widely in the medical research. Analytical methods of the mutivariate regression model including multiple linear regression, logistic regression, Poisson regression and Cox proportional hazard model were introduced in this article. The contents of the article covered the application conditions of regression models, analytical procedures, strategies of selecting independent variables, extended discussions of regression models and application notes. It is expected that authors could understand the principle of the mutivariate regression model, accurately use these analytical methods in their research, improve the efficiency of data utilization, and enhance the level of statistical analyses.
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Logistic regression is a kind of multiple regression method to analyze the relationship between a binary outcome or categorical outcome and multiple influencing factors, including multiple logistic regression, conditional logistic regression, polytomous logistic regression, ordinal logistic regression and adjacent categorical logistic regression. This paper illustrates the basic principle, independent variable selection and assignment, applied condition, model evaluation and diagnosis for multiple logistic regression model. Moreover, the principle and application for polytomous logistic regression and ordinal logistic regression models were also introduced. By providing SAS codes and detailed explanations of the result for an example of obesity, readers could be able to better understand logistic regression model, and apply this method correctly to their research and daily work, so as to improve their capacity of the data analysis.
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Multiple Linear Regression (MLR) is a generalization of simple linear regression and is one of the commonly used models in multivariate statistical analysis. This article introduces the MLR model from the perspective of practical application. Four parts, including basic principle, application examples, the application condition and diagnosis, and the extension of the model, are sequentially illustrated in this article. Particularly, in the last part, alternative methods of the model are introduced when the application condition of the model is not met. We sincerely hope that this article could make our audiences have a better understanding of the MLR model in order to improve the efficiency of data utilization and statistical analysis by correctly performing this model in their research.
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Objective To study the prevalence of musculoskeletal disorders (MSDs) and related factors in female greenhouse workers.Method A questionnaire survey was conducted among 851 female greenhouse workers in Shandong province in 2015.Results The incidence of MSDs among the female greenhouse workers was 82.79％.For the MSDs in female greenhouse workers,the top four affected body sites were low back (65.82％),knees (49.10％),neck (25.75％) and shoulder (23.47％).Multivariate logistic regression analysis showed that age ≥50 years (OR=2.098,95％CI:1.353-3.252),working years ≥20 (OR=1.703,95％CI:1.116-2.599),repetitive work (OR=1.903,95％CI:1.183-3.061),standing for prolonged time (OR=2.902,95％CI:1.183-7.120) and frequent slightly bending down (OR=2.979,95％ CI:1.823-4.867) were the main risk factors for MSDs in female greenhouse workers.Aiding tools was the protective factor (OR=0.400,95％ CI:0.229-0.697).Conclusions The findings showed a relatively higher prevalence of MSDs in female greenhouse workers.It is necessary to take appropriate measures to prevent and control the incidence of MSDs in female greenhouse workers.
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Objective To study the prevalence of musculoskeletal disorders (MSDs) and related factors in female greenhouse workers.Method A questionnaire survey was conducted among 851 female greenhouse workers in Shandong province in 2015.Results The incidence of MSDs among the female greenhouse workers was 82.79％.For the MSDs in female greenhouse workers,the top four affected body sites were low back (65.82％),knees (49.10％),neck (25.75％) and shoulder (23.47％).Multivariate logistic regression analysis showed that age ≥50 years (OR=2.098,95％CI:1.353-3.252),working years ≥20 (OR=1.703,95％CI:1.116-2.599),repetitive work (OR=1.903,95％CI:1.183-3.061),standing for prolonged time (OR=2.902,95％CI:1.183-7.120) and frequent slightly bending down (OR=2.979,95％ CI:1.823-4.867) were the main risk factors for MSDs in female greenhouse workers.Aiding tools was the protective factor (OR=0.400,95％ CI:0.229-0.697).Conclusions The findings showed a relatively higher prevalence of MSDs in female greenhouse workers.It is necessary to take appropriate measures to prevent and control the incidence of MSDs in female greenhouse workers.
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Liquid biopsy has recently become a hot research topic which can be applied in the diagnosis,prognosis evaluation and treatment guiding of cancers by detecting the circulating tumor cells(CTC) in blood or body fluid, circulating cell-free DNA (cfDNA), circulating cell-free RNA (cfRNA), exosomes and the newly-found tumor-educated platelet (TEP). Liquid biopsy is much simpler, faster, safer and more economical compared with the traditional methods of biopsy, which can help to get a more comprehensive understanding of the tumor heterogeneity and conform to the concept of precision medicine. This review summarizes the progress of CTC, cfDNA, cfRNA, TEP and exosomes, and discusses the exploration of liquid biopsy in the future.
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Objectives To compare prospective memory (PM) deficits with retrospective memory (RM) deficits and to explore the correlation between PM and RM in chronic schizophrenia. Methods Fifty chronic schizophrenia pa?tients and fifty healthy controls were recruited. The PM performance [event-based PM (EBPM) and time-based PM (TB?PM)] were evaluated by the Chinese version of the Cambridge Prospective Memory Test (C-CAMPROMPT); working memory (WM) was evaluated by the digital span subtest (DS);immediate auditory logical memory (IALM), delayed audito?ry logical memory (DALM), immediate visual reproduction memory (IVRM) and delayed visual reproduction memory (DVRM) were evaluated by the logical memory and visual reproduction subtest. The score of each test was transformed to comparable standard score. Results Patients performed significantly worse on EBPM [(7.9 ± 3.4) vs. (13.7 ± 2.9)], TBPM [(6.9±3.6) vs. (13.0±3.2)], DS [sequence:(5.8±2.0) vs. (7.5±2.2);backward:(6.5±1.9) vs. (8.2±2.8)], IALM [(8.3±3.1) vs. (11.9 ± 2.5)], DALM [(7.4 ± 3.7) vs. (11.8 ± 2.6)], IVRM [(8.0 ± 2.7) vs. (11.2 ± 3.8)], and DVRM [(7.7 ± 3.5) vs. (10.8 ± 2.7)] scores than controls (P0.05). The performance of PM in chronic schizophrenia was significantly related to DS (sequence and backward), IALM, DALM and DVRM (P<0.05), but not IVRM (P=0.155). Conclusion:There are greater prospective memory deficits than retrospective memory deficits in chron?ic schizophrenia and the prospective memory deficits are correlated with the retrospective memory deficits in chronic schizophrenia.
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Objective To explore the reliability and validity of the computerized Chinese version of Cambridge Prospective Memory Test (C-CAMPROMPT) for assessment of prospective memory (PM) in chronic schizophrenia patients. Methods 50 patients and 50 healthy controls formed the study sample. PM performance was measured with computerized C-CAMPROMPT, while the Wechsler Adult Memory Scale-Forth Edition (WMS-IV), Wisconsin Card Sorting Test (WCST) and Category Fluency Test (CFT) were administered to assess logical memory (LM), visual representation (VR), executive function and processing speed. Results The test-retest reliability (0.981, P<0.001), split half reliability (0.627, P<0.001) and internal consistency reliability (0.742) of C-CAMPROMPT were satisfied. The scores of C-CAM-PROMPT and its subtest in schizophrenia were lower than that in healthy control (P<0.001). The performance of PM in patients with schizo-phrenia closely related to the scores of LM, VR, WCST-CC and CFT (r=0.34~0.89, P<0.05). The sensitivity (86%) and specificity (92%) of the scale were satisfied. Factor analysis extracted 2 factors. Conclusion The computerized C-CAMPROMPT shows a good reliability and validity for assessment of PM function in chronic schizophrenia, and is a sensitive, adaptable, stable instrument.
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Objective To investigate the expression of miR-218 in cervical cancer tissues and bioinformatically analyze the target genes of miR-218 to provide theoretical basis on further studies of miR-218 functions in cervical cancer.Methods miRNA array was applied to detect miRNA expression profile in cervical cancer tissues,and real-time RT-PCR was used for validation.The bioinformatic analysis of the target genes of miR-218 involved gene ontology and signal transduction pathway enrichment was performed.Results miR-218 expression significantly decreased in cervical cancer tissues compared with that of normal cervical tissues.The functions of predicted target genes of miR-218 were enriched in biological regulation,adhesion and motion,proteometabolism,cellular differentiation,protein binding and other biological processes and molecular functions.According KEGG pathway database,the predicted target genes involved in pathway in cancer,adherent junction,focal adhesion,prostate cancer,chronic myeloid leukemia,melanoma,and other signal transduction pathways.Conclusions miR-218 expression significantly decreases in cervical cancer tissues.Some of the predicted target genes of miR-218 are significantly enriched in tumor related with signaling pathways.